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Abstract


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IJCPS JOURNAL-Vol 6 Issue 6, Nov - Dec 2017

Pages: 39-47

DNA Binding/Cleavage Studies of Copper(II) Complexes Containing

Heterocyclic Bases, L-Serine and Semicarbazide

Author: S. DHAKSHANAMOORTHY, M. MURALI KRISHNAN, M.N. ARUMUGHAM

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Abstract

Two new copper(II) complexes, [Cu(phen)(L-Ser)(Sc)]NO3 (1), [Cu(bpy)(L-Ser)(Sc)]NO3 (2) [L-ser = L-serine, Sc = semicarbazide, phen = 1,10-phenanthroline, bpy = 2,2’-bipyridyl), were prepared and fully characterized using elemental analyses, electronic, FT-IR and EPR spectrum. The complexes (1 & 2) bind to calf-thymus DNA (CTDNA) revealed by UV-vis spectral, thermal denaturation, fluorescence spectral, viscosity and cyclic voltammetry methods. The obtained results indicated that binding activities of complex 1 to DNA was intercalatative mode and complex 2 to DNA was partial intercalative mode, also complexes 1 and 2 binding with supercoiled pBR322 DNA was observed.

Keywords: DNA binding, copper(II) complex, 1, 10-phenanthroline, L-serine

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